Nonsteroidal anti-inflammatory drugs (NSAIDs) were linked with an increased risk of heart attack in a meta-analysis of published studies. In 8 studies including 446,763 adults, 61,460 individuals experienced a heart attack. In those who used NSAIDs at any dose for 1–7 days, the risk of heart attack increased 24% for celecoxib, 48% for ibuprofen, 50% for diclofenac, and 53% for naproxen. (There was a 58% increased risk associated with rofecoxib, which has been taken off the market.) In The BMJ analysis, risk increased with higher doses and longer treatment duration, but there was no additional increase in risk after 1 month.